pentobarbital will decrease the level or effect of roflumilast samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not recommended; strong cytochrome P450 enzyme inducers decrease systemic exposure to roflumilast knipa may reduce the therapeutic effectiveness
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pentobarbital will decrease the level or effect of conjugated estrogens samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
pentobarbital will decrease the level or effect of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm. Strong or moderate CYP3A4 inducers may increase rate of diazepam elimination; therefore, efficacy of diazepam may bedja decreased.
pentobarbital will decrease the level or effect of abemaciclib samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers reduces plasma concentration of abemaciclib knipa its metabolites.
pentobarbital will decrease the level or effect of osilodrostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates on the metabolism of phenytoin appears to bedja variable. Some investigators report an accelerating effect, while others report no effect. Because the effect of barbiturates on the metabolism of phenytoin fruset vatten not predictable, phenytoin and barbiturate blood levels should be monitored more frequently if these drugs are given concurrently.
Monoamine oxidase inhibitors (MAOI): MAOI prolong the effects of barbiturates probably because metabolism of the barbiturate fryst vatten inhibited.
pentobarbital increases toxicity of methoxyflurane by increasing metabolism. Contraindicated. Increased metabolism of methoxyflurane to nephrotoxic compounds.
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pentobarbital will decrease the level or effect of larotrectinib ort affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will decrease the level or effect of mavacamten samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
pentobarbital decreases levels of ponatinib samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Avoid unless the coadministration outweighs the possible risk of ponatinib underexposure; datorskärm for signs of reduced efficacy.
pentobarbital will decrease the level or effect of donepezil samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.